N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid
5-formyltetrahydrofolic acid
CAS: 58-05-9
Molecular Formula: C20H23N7O7
N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid - Names and Identifiers
| Name | 5-formyltetrahydrofolic acid |
| Synonyms | leucoverin Folinic Acid 5-formyltetrahydrofolate N5-formyl-tetrahydrofolate 5-formyltetrahydrofolic acid 5-formyl-5,6,7,8-tetrahydrofolate N5-formyl-5,6,7,8-tetrahydrofolate 5-formyl-5,6,7,8-tetrahydropteroyl-l-glutamicacid N-(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}benzoyl)glutamic acid N-(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid 2-[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]aminopentanedioic acid N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid |
| CAS | 58-05-9 |
| EINECS | 200-361-6 |
| InChI | InChI=1/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12-,13-/m0/s1 |
N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid - Physico-chemical Properties
| Molecular Formula | C20H23N7O7 |
| Molar Mass | 473.44 |
| Density | 1.4485 (rough estimate) |
| Melting Point | 245°C (rough estimate) |
| Boling Point | 573.92°C (rough estimate) |
| Specific Rotation(α) | D20 +14.26° (c = 3.42 as anhydr Ca salt) |
| Water Solubility | >1350g/L(25 ºC) |
| pKa | 3.1, 4.8, 10.4(at 25℃) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Refractive Index | 1.6800 (estimate) |
| In vitro study | MTX alone induces a concentration-related increase in % micronucleated binucleated cells (MNBN) and % aberrant cells (Abs). There is a decrease in nuclear division index (NDI) with increase in MTX concentration. Similarly, the mitotic index (MI) also decreases in all concentrations of MTX tested. The addition of Folinic acid at 50 μg/ mL significantly reduces % MNBN (40-68%) and % Abs (36-77%). Inhibition is also seen at 5 μg/ mL Folinic acid (12 to 54% for MNBN and 20 to 61% for Abs) . |
![N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid](http://res.chembk.com/assets/str/2d/5/58/58-05-9.png)
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View History
N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid
727664-33-7
5,8-Isoquinolinedione, 6-chloro-7-hydroxy-
4-(6-Bromoimidazo[1,2-a]pyridin-3-yl)pyrimidin-2-amine
3,3-dichloroazepan-2-one
Ethyl 4-({[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}carbonyl)-5-methylisoxazole-3-carboxylate 97%
3-(2-chlorophenyl)-3-oxo-2-(phenylhydrazono)propanenitrile
88639-60-5
1-[1-(propan-2-yl)-1H-1,2,3-triazol-4-yl]ethan-1-ol
tert-Butyl 2-(methoxymethyl)azetidine-1-carboxylate
727664-33-7
5,8-Isoquinolinedione, 6-chloro-7-hydroxy-
4-(6-Bromoimidazo[1,2-a]pyridin-3-yl)pyrimidin-2-amine
3,3-dichloroazepan-2-one
Ethyl 4-({[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}carbonyl)-5-methylisoxazole-3-carboxylate 97%
3-(2-chlorophenyl)-3-oxo-2-(phenylhydrazono)propanenitrile
88639-60-5
1-[1-(propan-2-yl)-1H-1,2,3-triazol-4-yl]ethan-1-ol
tert-Butyl 2-(methoxymethyl)azetidine-1-carboxylate